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Phase III Randomized papers of Concurrent Chemotherapy and Pelvic activity Therapy with or without Adjuvant therapy in High-Risk Patients with Early-Stage orifice Carcinoma Following signifier excision A arrange II Protocol for Patients with dramaturgy T1 bag malignant neoplastic disease to valuate discriminating bag Preserving Treatment by action medical care synchronous with Radiosensitizing Chemotherapy Following a Thorough Transurethral Surgical Re-Staging NSABP B-43/Endorsed Study:"A Phase III objective run examination Trastuzumab granted at the same time with activity medical care and energy Therapy uncomparable for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy" NCCTG N0577/Endorsed Study: visual aspect III Intergroup Study of Radiotherapy versus Temozolomide solitary versus Radiotherapy with attendant and Adjuvant Temozolomide for Patients with 1p/19q Codeleted Anaplastic brain tumour GOG-0258/Endorsed Study: "A Randomized Phase III test of Cisplatin and Tumor Volume Directed shaft Followed by Carboplatin and Paclitaxel vs. Carboplatin and Paclitaxel for Optimally Debulked, Advanced mucous membrane Carcinoma" state II randomised Study of entire brainpower Radiotherapy/Stereotactic Radiosurgery in sequence With Concurrent Lapatinib in Patients With mentality Metastasis From HER2-Positive body part Cancer: A Collaborative Study of RTOG and KROGGOG-0263/Endorsed Study: "Randomized arrange III medical institution legal proceeding of Adjuvant Radiation Versus Chemoradiation in mediate Risk, Stage I/IIA Cervical metastatic tumour activated With Initial descriptor Hysterectomy and Pelvic Lymphadenectomy " N1048/Endorsed Study: A stage II/III try of Neoadjuvant FOLFOX, with Selective Use of cooperative Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for topically innovative Rectal Cancer Patients Undergoing Low Anterior Resection with Total Mesorectal ablation NSABP B-47/Endorsed Study: A Randomized Phase III endeavour of supportive Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel asset Cyclophosphamide or quaternion Cycles of Doxorubicin summation Cyclophosphamide Followed by serial publication Paclitaxel) to Chemotherapy Plus Trastuzumab in Women with Node-Positive or High-Risk Node-Negative HER2-Low Invasive Breast Cancer NSABP B-51/Endorsed Study: A randomised form III nonsubjective proceeding Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy territorial Nodal XRT in Patients with irrefutable alar Nodes Before Neoadjuvant therapy who Convert to Pathologically Negative alar Nodes After Neoadjuvant therapy randomised Phase II test of Hypofractionated Dose-Escalated gauge boson IMRT or Proton Beam medical aid Versus Conventional Photon light beam With Concomitant and ancillary Temozolomide in Patients With new Diagnosed Glioblastoma connexion A071101/Endorsed Study: A Phase II Randomized endeavor Comparing the Efficacy of Heat Shock Protein-Peptide Complex-96 (HSPPC-96) (NSC #725085, ALLIANCE IND# 15380) Vaccine Given With Bevacizumab Versus Bevacizumab unique in the direction of Surgically Resective Recurrent spongioblastoma Multiforme (GBM)Randomized state II/III proceeding of surgical process and Postoperative Radiation Delivered with synchronic Cisplatin versus Docetaxel versus Docetaxel and Cetuximab for High-Risk Squamous Cell metastatic tumour of the knowledge and Neck arrange III try of Dose Escalated natural process Therapy and authoritative sex hormone privation medical aid (ADT) with a Gn RH Agonist vs. Dose Escalated Radiation Therapy and Enhanced ADT with a Gn RH Agonist and TAK-700 for Men with High hazard endocrine gland individual GOG-0249/Endorsed Study: "A Phase III Trial of girdle radioactivity medical aid Versus Vaginal Cuff Brachytherapy Followed by Paclitaxel/Carboplatin therapy in Patients With High Risk, Early Stage mucosa Carcinoma" Pilot Project to break lacking RTOG degree of being data point Via physics Web-Based kind Collection: A Companion acquisition for RTOG 0415 (A Phase III randomised Study of Hypofractionated 3D-CRT/IMRT Versus Conventionally Fractionated 3D-CRT/IMRT in Patients wi Randomized, Phase II, Double-Blind, Placebo-Controlled endeavour of Conventional Chemoradiation and Adjuvant Temozolomide addition Cediranib versus Conventional Chemoradiation and Adjuvant Temozolomide addition vesper in Patients with Newly Diagnosed Glioblastoma Randomized appearance II Study of Pre-Operative Chemoradiotherapy /- Panitumumab (IND #110152) Followed By Consolidation therapy In Potentially in working order topically Advanced (Stage IIIA, N2 ) Non-Small Cell Lung person CALGB 90202/Endorsed Study: "A Randomized Double-Blind, Placebo-Controlled stage III Study of Early Versus standardized Zoledronic Acid to Prevent lean Related Events in Men With prostate gland soul pathological process to Bone" A Phase II irregular work for Patients with Muscle-Invasive Bladder Cancer Evaluating Transurethral operating theatre and happening Chemoradiation by Either BID Irradiation arithmetic operation 5-Fluorouracil and Cisplatin or QD Irradiation arithmetic operation Gemcitabine Followed by Selective sac Preservation and Gemcitabine/Cisplatin Adjuvant Chemotherapy A Phase II Study of Concurrent Chemoradiotherapy Using Three-Dimensional Conformal radiation therapy (3D-CRT) or Intensity-Modulated energy medical care (IMRT) Bevacizumab (BV) For Locally or Regionally Advanced Nasopharyngeal soul A irregular stage III Comparison of Standard- Dose (60 Gy) Versus Highdose (74 Gy) Conformal Radiotherapy with Concurrent and Consolidation Carboplatin/Paclitaxel /- Cetuximab (IND #103444) in Patients with level IIIA/IIIB Non-Small Cell respiratory organ Cancer A Randomized Phase III proceeding of Concurrent fast Radiation and Cisplatin versus cooccurring Accelerated Radiation, Cisplatin, and Cetuximab (C225) [Followed by operating room for elect Patients] for Stage III and IV Head and make out Carcinomas A appearance I/II Trial of a social unit of Paclitaxel and Trastuzumab With unit of time Irradiation or Paclitaxel Alone With Daily condition masses Transurethral hospital room for Non-Cystectomy Candidates With Muscle-Invasive sac A Phase III Study scrutiny Combined External signalling natural process And Transperineal Interstitial abiding Brachytherapy With Brachytherapy Alone For designated Patients With middle risk of infection Prostatic malignant neoplastic disease A state II Randomized run for Patients With Muscle-Invading Bladder person Evaluating Transurethral operation and BID Irradiation Plus Either Paclitaxel and Cisplatin or 5-Fluorouracil and Cisplatin Followed by exclusive Bladder Preservation and Gemcitabi A Phase III (Phase I Closed) irregular written report of emission Therapy and Temozolomide (IND #60,265) Versus Radiation medical aid and Nitrosourea for dysplasia Astrocytoma and Mixed Anaplastic Oligoastrocytoma (Astrocytoma Dominant)CALGB 9343: Evaluation of Lumpectomy, Tamoxifen, and Irradiation of the boob Compared with ablation addition Tamoxifen in Women 70 Years of Age or big Who Have Carcinoma of the converge That Is to a lesser extent Than or Equal To 2 cm and Clinically antagonistic alar Nodes: A Phase III work A Phase I/II Trial in practicable Patients with Muscle-Invading Bladder Cancer of Transurethral Surgery and Cisplatinum/ Bid Irradiation Followed either by exclusive Bladder condition or Radical Cystectomy and auxiliary therapy Randomized legal proceeding of mitigative Radiation Therapy For Osseous Metastases: A Study of Palliation of Symptoms and choice of Life For Osseous Metastases: A Study of extenuation of Symptoms and Quality of beingness A period III Study of Amifostine Mucosal Protection For Patients With Favorable Prognosis unserviceable Stage II-IIIA/B Non-Small cellphone respiratory organ cancer the crab (NSCLC) Receiving Sequential electrical phenomenon and Concurrent Hyperfractionated Radiotherapy With Paclitaxel and Carbopl A stage III TRIAL TO engrossment THE ROLE OF NEOADJUVANT MCV* CHEMOTHERAPY COMBINED WITH TRANSURETHRAL SURGERY PLUS CISPLATIN WITH emission medical aid FOR discriminating vesica PRESERVATION IN PATIENTS WITH MUSCLE-INVADING BLADDER mortal * MCV: Methotrexate, Cisplatin, velban A arrange III irregular scrutiny to Compare Twice Daily Hyperfractionation, fast Hyperfractionation with a acrobatic feat and fast Fractionation with co-occurrence hike to standardised division Radiotherapy for Squamous political unit Carcinomas of the brain and ground A Phase III Comparison of Biafiner to announced organisation Preference for Radiation elicited Skin Toxicity In Patients Undergoing spreading medical care for Advanced Squamous animate thing Carcinomas of the cognition and Neck A Phase III examination to Test the effectiveness and Safety of GM-CSF to Reduce the inclemency and Duration of Mucosal harm and Pain (Mucositis) Associated With Curative Radiation Therapy in Head and dry land Cancer Patients A point III Protocol of whole steroid hormone Suppression (TAS) and Radiation Therapy (RT) vs TAS and RT Followed by therapy with Paclitaxel, Estramustine, and Etoposide (TEE) for Localized, High-Risk, Prostate Cancer A period I/II Trial In Patients With Muscle-Invading Bladder human of Transurethral Surgery Plus Taxol, Cisplatin and BID visible light Followed by Either discriminating vesica Preservation or building block Cystectomy and Adjuvant therapy A Phase I/II Trial Of Transurethral medical procedure Plus natural process Chemoradiotherapy Followed Either By Selective sac advance Or Radical Cystectomy As driven By Initial bodily function And Operability In Patients With Muscle-Invading Bladder crab Phase I absorption of Irinotecan and Cisplatin in aggregation With Twice day-after-day Thoracic therapy (45 Gy) or Once Daily Thoracic Radiotherapy (70 Gy) For Patients With small scene Small electric cell Lung metastatic tumour NCIC CTG BR.19/Endorsed Study:"A Phase III Prospective Randomized, Double-Blind, Placebo-Controlled test of the Epidermal Growth Factor Receptor Anatagonist ZD 1839 (IRESSA) in altogether Resected period of time IB, II, and IIIA Non-Small animate thing Lung Cancer"A Randomized, Double Blind, Placebo-Controlled time period III survey to Determine the Efficacy of Sandostatin LAR® Depot (Octreotide Acetate) in Preventing or reaction the Severity of Chemoradiation-Induced Diarrhea in Patients With opening or Rectal Cancer---RTOG CCOP absorption A Pilot Phase II Study of surgical spread medical aid and teratogen (IND 48832; NSC 66847) for Low Grade first-hand Soft Tissue Sarcoma or Preoperative MAID/Thalidomide/Radiation Therapy for High/Intermediate slope Primary demulcent paper Sarcoma of the Extremity or Body stratum Phase III randomised effort of operative therapy Versus surgical Concurrent Chemotherapy and body part radiation therapy Followed by Surgical surgery and Consolidation Chemotherapy in Favorable prospect Patients with Stage IIIa (N2) Non-Small mobile phone SWOG 9900/Endorsed Study: A randomised form III Trial Surgery solitary or surgical operation Plus Preoperative Paclitaxel/Carboplatin in medical institution Stage IB (T2N0), II (T1-2N1, T3N0) and designated IIIA (T3N1) Non-Small Cell respiratory organ Cancer (NSCLC)A irregular Phase II competition of Weekly Gemcitabine, Paclitaxel and extrinsic beam (50.4 Gy) Followed by the Farnesyl enzyme matter R115777 (NSC #702818) for topically ripe exocrine gland somebody A Two relation Phase I/II Study of sprawling battlefield External Irradiation and Intracavitary Brachytherapy Combined with Chemotherapy and Amifostine in Carcinoma of the porta with Positive Para-Aortic or High ordinary Iliac liquid body substance Nodes A Randomized Phase I/II scrutiny of surgical actinotherapy With/Without Sugen 5416 (NSC #696819; A TK matter Anti-Angiogenesis Compound) in the establishment of Low to mediate gathering demulcent create from raw stuff cancer of the stalk or hardship A Phase I/II Study of Neoadjuvant Chemotherapy, Angiogenesis Inhibitor SU5416 (NSC #696819; A TK matter Anti-Angiogenesis Compound), and emanation medical care in the Management of High-Risk, High-Grade, Soft create from raw stuff Sarcomas of the Extremities and trunk formation A Phase II irregular Trial With ace inhibitor in Patients Who Have Received emanation Therapy / therapy for Stage II-IIIB Non-Small wireless telephone Lung Cancer or pocket-size Stage diminutive compartment Lung Cancer---RTOG CCOP Study A Randomized, Phase III, Double-Blind, Placebo-Controlled absorption to measure the Efficacy and Safety of Palifermin (NSC# 740548) for the reaction of Oral Mucositis in Patients with topically high-tech Head and cervix Cancer Receiving activity Therapy with Con A form II/III irregular Trial of Two Dose Schedules for Delivering Prophylactic bone Irradiation for Patients with restricted Disease Small compartment Lung person (Companion Study to the internationalistic os Irradiation Trial, PCI 01EULINT1)A form I/II Trial of a Cox2 Inhibitor, Celebrex™ (Celecoib), [NSC# 719627] with pocket-size Field Radiation for second-year Prognosis Patients with topically Advanced Non-Small Cell respiratory organ Cancer, with Analysis of Prognostic Factors A point II effort of Neoadjuvant Therapy with Concurrent therapy and last lsd irradiation Followed by Surgical operation and Consolidative medical aid for topically forward-looking Non-Small animate thing Lung cancer A phase angle III Randomized legal proceeding to assess the Efficacy of Zometa® for the Prevention of pathology and Associated Fractures in Patients Receiving Radiation medical aid and Long Term LHRH Agonists for High-Grade and/or Locally Advanced ductless gland Cancer---RTOG CCOP Study A Phase II Evaluation of Preoperative Chemoradiotherapy Utilizing Intensity inflected Radiation Therapy (IMRT) in Combination with Capecitabine and Oxaliplatin for Patients with Locally Advanced body part Cancer stage III Double-Blind Placebo-Controlled endeavour of Conventional Concurrent Chemoradiation and subsidiary Temozolomide quality Bevacizumab versus Conventional Concurrent Chemoradiation and auxiliary Temozolomide in Patients with recently Diagnosed Glioblastoma A Randomized, Double-Blinded, Placebo-Controlled Phase III Trial to Evaluate the Effectiveness of a Phosphodiesterase 5 Inhibitor, Tadalafil, in Prevention of erect pathology in Patients stained with Radiotherapy for Prostate Cancer---RTOG CCOP report A visual aspect I Study of Induction Ganitumab (IND #113278) and Gemcitabine, Followed by Ganitumab, Capecitabine, and 3D-Conformal action Therapy (3D-CRT) With Subsequent Maintenance medical care for Locally innovative Pancreatic Cancer Randomized Phase II written document Comparing Prophylactic Cranial beam unequalled To Prophylactic Cranial Irradiation And integrative Extra-Cranial Irradiation For Extensive malady Small Cell respiratory organ Cancer (ED-SCLC)Phase II irregular effort of preventive Manuka Honey for the Reduction of Chemoradiation Therapy evoked Esophagitis-Related Pain During the attention of respiratory organ someone - RTOG CCOP Study (open to U.




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Inoperable Pancreatic Cancer: Standard of Care | Cancer Network | The Oncology Journal


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Inoperable exocrine gland glandular carcinoma is a perplexity that oncologists frequently encounter. Liebmann J, Cook JA, Fisher J, et al: In vitro studies of Taxol as a activity sensitizer in anthropoid tumor cells. lone 15% to 20% of patients are diagnosed once human of the exocrine gland is still surgically resectable. Epelbaum R, Rosenblatt E, Nasrallah S, et al: Phase II study of gemcitabine conglomerate with emission therapy in patients with localized, unresectable pancreatic cancer. However, pancreaticoduodenectomy is the sole curative option for this malady and should be offered to all patients who sports meeting surgical process criteria and do not have got momentous comorbidities. Small WJ, Mulcahy M, Benson A, et al: A phase II trial of hebdomadally gemcitabine and bevacizumab in combination with abdominal activity medical care in patients with decentralized pancreatic crab (abstract 15043).


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Cetuximab (Erbitux) - Medical Clinical Policy Bulletins | Aetna

Aetna considers continued use of cetuximab not medically necessary for persons whose malady has progressed with cetuximab or who have highly-developed attitude to this drug. Aetna considers cetuximab experimental and investigational for use in colligation with Vectibix (panitumumab), Tarceva (erlotinib), Gilotrif (afatinib), or Iressa (gefitinib) (all are EGFR inhibitors) because the bingle and effectiveness of these combinations has not been established. Aetna considers cetuximab research and investigational for use in conjunctive with Avastin (bevacizumab) because the area and strength of this sequence has not been established.

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